Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication.RRM2 performs a critical role in the malignant biological behaviors of cancers.The str